The Platelet in Uremia

Platelets and Platelet Phosphatides in Uremia

By Gsaw n ALTSCHULER, AARON J. MARcus AND H uims L. Uu i N I HE HEMORRHAGIC tendency which develops in uremia is a well recognized clinical entity but the pathogenesis of this complication is not understood.’ In the past defective blood coagulation2 as well as increased vascular fragility3 have been suggested. The possibility of a functional blood platelet abnormality was first noted by Lewis, ...

Platelet Function and Factor VIII in Uremia*

Platelets and platelet phosphatides in uremia.

By Gsaw n ALTSCHULER, AARON J. MARcus AND H uims L. Uu i N I HE HEMORRHAGIC tendency which develops in uremia is a well recognized clinical entity but the pathogenesis of this complication is not understood.’ In the past defective blood coagulation2 as well as increased vascular fragility3 have been suggested. The possibility of a functional blood platelet abnormality was first noted by Lewis, ...

Defective ADP-induced platelet factor 3 activation in uremia.

P ATIENTS \VITH UREMIA frequently have both prolonged bleeding times,11#{176} suggesting poor platelet plug formation, and impaired prothrombin consumption,1’2’46’#{176}14 ascribed to defective platelet factor 3 activalion. Considerable evidence points to the presence of a qualitative platelet defect in uremia, since such abnormalities cannot be attributed to the mild thrombocytopenia occasiona...

Reduced platelet thromboxane formation in uremia. Evidence for a functional cyclooxygenase defect.

A qualitative platelet abnormality and a bleeding tendency are frequently associated with renal failure and uremia. We demonstrated previously that uremic patients display an abnormal platelet aggregation to arachidonic acid and reduced malondialdehyde production in response to thrombin and arachidonic acid. The objectives of this investigation were: (a) to compare platelet prostaglandin (PG) a...